A gifted mathematician, Polish-born Stanislaw Ulam made contributions to set theory, topology, mathematical logic, and number theory, but is most widely remembered for his work in fostering the technical development of thermonuclear weapons. He was associated with Los Alamos Scientific Laboratories for most of the years between 1943 and 1965, and thereafter with the University of Colorado. These papers include personal and professional correspondence, manuscripts of both published and unpublished works, and memorabilia.

Edward Uhler Condon was a theoretical physicist at Princeton University and Westinghouse Laboratories who later served as director of the National Bureau of Standards (1945-1951), and as the director of research and development (1951-1954) and consulting physicist (1954-1974) at Corning Glass Works. The Condon Papers includes correspondence, notebooks, writings, photographs, and other materials concerning Condon's education, teaching, and his government, industrial, and academic.

After receiving his doctorate from Harvard in 1923, the physicist John Clarke Slater did postgraduate work at Cambridge University and on the continent working n quantum theory with both Niels Bohr and Werner Heisenberg. Slater was appointed to the head of the department of physics at MIT in 1930, which he and Karl Compton worked effectively to transform into one of international stature. His own work on the electromagnetic theory of microwaves was fundamental to the development of radar systems. During the Second World War, he was affiliated with the radiation laboratory and after he helped found the solid state and molecular theory group, the interdisciplinary Center for Materials Science and Engineering, the Research Laboratory of Electronics, and the Laboratory for Nuclear Science. After his retirement from MIT in 1966, Slater moved to the University of Florida, remaining active until his death in 1976. The Slater Papers contains a wealth of information on the development of physics at MIT, as well as Slater's post-1966 work at the University of Florida. There are about 133 (7 linear ft.) research notebooks, 1944-1976, and a long series (30 linear ft.) of folders, containing lectures, scientific notes, drafts of manuscripts and papers, correspondence during his collaboration with the Los Alamos Labs, 1966-1970, and extensive correspondence relating to the National Academy of Science. Information about American-Swedish exchange in quantum science is located in the correspondence with Per-Olov Löwdin.

A physicist with the Theoretical Division of Los Alamos Scientific Laboratory, Walter Goad became interested in molecular biology in the mid-1960s, devoting nearly all of his research to the analysis, storage and retrieval of information relating to nucleic acid sequences by the early 1970s. He was among the founders of GenBank, the world's first nucleic acid database, and was influential in the development of computational techniques for the analysis of DNA sequences. In the late 1980s, he served on the steering committee overseeing the establishment of the Human Genome Project. The Goad Papers relate primarily to the establishment and early operation of GenBank, the early phases of the Human Genome Project, and, more generally, to Goad's role as godfather of the new field of bioinformatics.